SiteSifter finds highly conserved DNA motifs embedded within coding regions. Each instance of a motif is scored based on the chance that its constituent codons are conserved over and above that required for amino acid conservation.

Find all conserved instances of a motif

Choose a known motif or a custom DNA sequence:
1.   Known motifs:
Or      2.   Enter a custom motif: (length 6-8)

with conservation in at least genomes (scoring only available for 17-genome conservation).



Find all conserved motifs contained in a given gene

Enter a gene symbol:     

with conservation in at least genomes (scoring only available for 17-genome conservation).



References
Forman J, Legesse-Miller A, Coller H (2008) A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proceedings of the National Academy of Sciences of the United States of America 105:39, 14879-14884. (Link)